Create a narrow targeted keywords list that you think identifies your site properly. Check Yahoo's Overture (searchmarketing.yahoo.com) or WordTracker (www.wordtracker.com) for ideas on selecting keywords. You can find out the effectiveness of your keywords. In WordTracker for instance, you can input your keyword to see how often people have searched for it. It also tells you how often a term is searched and how many pages appear for that term.
Once you identify the keywords, what do you do with them? One obvious thing to do is to add them inside the Meta Keywords tag. In addition, use the keywords generously throughout your page content. Search Engines love a site with fresh descriptive content filled with keywords. This means constantly updating your site with new, fresh content is vital to your overall SEO strategy.